Xu Lab
Xu Lab
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ABOUT THE LAB
Our lab uses and develops both computational and experimental tools to ask fundamental questions about microbiology. We are especially interested in how microbial communities assemble, adapt, and impact their environments and hosts.
Recent Publications
Metatranscriptomics uncovers diurnal functional shifts in bacterial transgenes with profound metabolic effects
Diurnal rhythmicity in the gut maintains gut integrity, circadian rhythms, and metabolic homeostasis. However, existing studies focus …
Stephany Flores Ramos
,
Nicole Siguenza
,
Wuling Zhong
,
Ipsita Mohanty
,
Amulya Lingaraju
,
R. Alexander Richter
,
Smruthi Karthikeyan
,
April L. Lukowski
,
Qiyun Zhu
,
Wilhan D.G. Nunes
,
Jasmine Zemlin
,
Zhenjiang Zech Xu
,
Jeff Hasty
,
Pieter C. Dorrestein
,
Satchidananda Panda
,
Rob Knight
,
Amir Zarrinpar
Cite
DOI
RNA–ligand interaction scoring via data perturbation and augmentation modeling
Despite recent advances in RNA-targeting drug discovery, the development of data-driven deep learning models remains challenging owing …
Hongli Ma
,
Letian Gao
,
Yunfan Jin
,
Jianwei Ma
,
Yilan Bai
,
Xiaofan Liu
,
Pengfei Bao
,
Ke Liu
,
Zhenjiang Zech Xu
,
Zhi John Lu
Cite
DOI
DeepPhylo: Phylogeny-Aware Microbial Embeddings Enhanced Predictive Accuracy in Human Microbiome Data Analysis
Microbial data analysis poses significant challenges due to its high dimensionality, sparsity, and compositionality. Recent advances …
Bin Wang
,
Yulong Shen
,
Jingyan Fang
,
Xiaoquan Su
,
Zhenjiang Zech Xu
Cite
DOI
Systematic Analyses Uncover Robust Salivary Microbial Signatures and Host-Microbiome Perturbations in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy in the oral-maxillofacial region with a poor prognosis. Oral microbiomes …
Zewen Han
,
Yichen Hu
,
Xin Lin
,
Hongyu Cheng
,
Biao Dong
,
Xuan Liu
,
Buling Wu
,
Zhenjiang Zech Xu
Cite
DOI
Impacts of Food Additives on Gut Microbiota and Host Health
The rapidly expanding food industry necessitates the use of food additives to achieve specific purposes. However, this raises new …
Ping Li
,
Ru Qu
,
Ming Li
,
Ping Sheng
,
Liang Jin
,
Xiaochang Huang
,
Zhenjiang Zech Xu
Cite
DOI
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